My Research
Chromosome segregation is an essential process in the cells of all living organisms.
It ensures that each daughter cell inherits a complete copy of the parental genetic information. However not only is the genetic material of a cell compacted by three magnitudes, but it is also continuously in use and requires packaging in a specific manner to allow for vital DNA-based processes including transcription, replication and repair.
Many of the underpinning mechanisms of in vivo chromosome segregation and replication are not well understood.
One key process is the ParA-ParB-parS system which actively segregates the chromosome during replication through ParB-DNA spreading.
This system relies upon a CTP switch, and it is believed this is one of many vital biological systems that have evolved to use a cytidine nucleoside-based switch.
I joined the Dr Tung Le’s group in 2021 as a postdoctoral researcher on a five-year Wellcome Trust funded project.
Previous Research
My PhD work focused on the regulation of development and antibiotic production in Streptomyces bacteria.
No darkness would ever settle upon those lamps, as no darkness had settled upon them for hundreds of years. It seemed dreadful that the town should blaze for ever in the same spot; dreadful at least to people going away to adventure upon the sea, and beholding it as a circumscribed mound, eternally burnt, eternally scarred. From the deck of the ship the great city appeared a crouched and cowardly figure, a sedentary miser.
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